Project AURIONAI Use-Cases Research & Innovation
Healthcare

Protein Language Models and Design

Protein LMs for generation and design.

scientific
3named models
33candidates
0deployments
0in Indonesia

Named Models

EvolutionaryScaleESM3 98BEvolutionaryScaleReleasedJun 2024Runs onnot in the notesClassscientificClosed 98B ESM3 protein model.Commercial use: not stated; Jakarta hosting: unknown; Indonesian support: not statedEvolutionaryScaleESM3 open 1.4BEvolutionaryScaleReleasedJun 2024Runs onnot in the notesClassscientificOpen 1.4B ESM3 model released under MIT.Commercial use: allowed; Jakarta hosting: unknown; Indonesian support: not statedMetaESM-2 / ESMFoldMetaReleasednot in the notesRuns onnot in the notesClassscientificMeta protein language model; ancestor of ESM C (unverified).Commercial use: not stated; Jakarta hosting: unknown; Indonesian support: not stated
Where this comes from
Models the research names for this use case. Research, with sources on each model record.

Who Runs It

No deployment is recorded for this use case.

Where this comes from
Documented uses by named organisations. The evidence column says who made the claim.

Candidate Models

Boltz PBCBoltz-2Boltz PBC, MIT (Jameel Clinic), Recursion, scientificReleasedJun 2025open weightshas scoreslast 18 monthsByteDanceProtenix-v1ByteDance, scientificReleasedFeb 2026open weightslast 18 monthsOpenFold consortiumOpenFold3 (preview)OpenFold consortium, scientificReleasedOct 2025open weightslast 18 monthsYale UniversityC2S-Scale-Gemma-2-27BYale University, Google, Google DeepMind, scientificReleasedOct 2025open weightslast 18 monthsYale UniversityC2S-Scale-Gemma-2-2BYale University, Google, Google DeepMind, scientificReleasedOct 2025open weightslast 18 monthsIBMSuryaIBM, NASA, scientificReleasedAug 2025open weightslast 18 monthsByteDanceProtenix-Mini / Mini+ByteDance, scientificReleasedJul 2025open weightslast 18 monthsMicrosoft AIDayhoff-3b-GR-HM-cMicrosoft AI, scientificReleasedJul 2025open weightslast 18 monthsGoogle DeepMindAlphaFold 3Google DeepMind, Isomorphic Labs, scientificReleasedMay 2024open weightshas scoresEvolutionaryScaleESMFold2EvolutionaryScale, scientificReleasedMay 2026last 18 months

Showing 10 of 33. All models of this class

Where this comes from
Derived, not researched: models in the directory whose class matches a class this use case uses, excluding family records and models shut down or deprecated. Ranked by how many fit facts they meet, then by release date. Each fit fact is read from the model record.

Sources

  1. Evolutionary Scale , ESM3: Simulating 500 million years of evolution with a language model evolutionaryscale.ai https://www.evolutionaryscale.ai/blog/esm3-release

To cite this page: Project AURION, AI Use-Cases Research & Innovation, "Protein Language Models and Design", https://aurion.semai.id/usecases/hc-protein-design/, records of October 2026.