Project AURIONAI Use-Cases Research & Innovation
Healthcare

Protein Structure and Complexes

Diffusion structure models for drug discovery.

scientific
4named models
32candidates
1deployments
0in Indonesia

Named Models

Boltz PBCBoltz-1Boltz PBC, MIT (Jameel Clinic)ReleasedNov 2024Runs onnot in the notesClassscientificBoltz-1Predecessor of Boltz-2.Commercial use: allowed; Jakarta hosting: unknown; Indonesian support: not statedBoltz PBCBoltz-2Boltz PBC, MIT (Jameel Clinic), RecursionReleasedJun 2025Runs onsingle datacentre GPUClassscientificBoltz-2Co-folding and binding-affinity model; vendor claims it approaches FEP accuracy at about 1000x speed; evaluated on FEP+, CASP16, MF-PCBA.Commercial use: allowed; Jakarta hosting: unknown; Indonesian support: not statedBoltz PBCBoltzGenBoltz PBCReleasednot in the notesRuns onnot in the notesClassscientificBoltzGenBoltz design model; its licence is described only as permissive.Commercial use: not stated; Jakarta hosting: unknown; Indonesian support: not statedGoogle DeepMindAlphaFold 3Google DeepMind, Isomorphic LabsReleasedMay 2024Runs onsingle datacentre GPUClassscientificBiomolecular structure model. At CASP16 the AF3 server was comparable to, not ahead of, the best groups (B8); AF3 was the core engine of most top groups.Commercial use: non-commercial; Jakarta hosting: unknown; Indonesian support: not stated
Where this comes from
Models the research names for this use case. Research, with sources on each model record.

Who Runs It

contract signed, 1
PfizerPfizerCountry: not in the notesBoltz models fine-tuned on Pfizer dataVendor: Boltz PBCcontract signedDate8 Jan 2026Pfizer owns the compoundsEvidence: company statementConfidence: lowSource: intuitionlabs.ai, boltz.bio
Where this comes from
Documented uses by named organisations. The evidence column says who made the claim.

Candidate Models

ByteDanceProtenix-v1ByteDance, scientificReleasedFeb 2026open weightslast 18 monthsOpenFold consortiumOpenFold3 (preview)OpenFold consortium, scientificReleasedOct 2025open weightslast 18 monthsYale UniversityC2S-Scale-Gemma-2-27BYale University, Google, Google DeepMind, scientificReleasedOct 2025open weightslast 18 monthsYale UniversityC2S-Scale-Gemma-2-2BYale University, Google, Google DeepMind, scientificReleasedOct 2025open weightslast 18 monthsIBMSuryaIBM, NASA, scientificReleasedAug 2025open weightslast 18 monthsByteDanceProtenix-Mini / Mini+ByteDance, scientificReleasedJul 2025open weightslast 18 monthsMicrosoft AIDayhoff-3b-GR-HM-cMicrosoft AI, scientificReleasedJul 2025open weightslast 18 monthsEvolutionaryScaleESMFold2EvolutionaryScale, scientificReleasedMay 2026last 18 monthsByteDanceProtenix-v2ByteDance, scientificReleasedApr 2026last 18 monthsChai DiscoveryChai-2Chai Discovery, scientificReleasedJul 2025last 18 months

Showing 10 of 32. All models of this class

Where this comes from
Derived, not researched: models in the directory whose class matches a class this use case uses, excluding family records and models shut down or deprecated. Ranked by how many fit facts they meet, then by release date. Each fit fact is read from the model record.

Sources

  1. Accurate structure prediction of biomolecular interactions with AlphaFold 3 - Nature nature.com https://www.nature.com/articles/s41586-024-07487-w
  2. GitHub - google-deepmind/alphafold3: AlphaFold 3 inference pipeline. github.com https://github.com/google-deepmind/alphafold3
  3. intuitionlabs.ai/articles/open-source-ai-drug-discovery-boltz-... https://intuitionlabs.ai/articles/open-source-ai-drug-discovery-boltz-pfizer

To cite this page: Project AURION, AI Use-Cases Research & Innovation, "Protein Structure and Complexes", https://aurion.semai.id/usecases/hc-protein-structure/, records of October 2026.