scientific
ESM C
EvolutionaryScale protein language model; repo says available under the MIT licence.
Levelmodel
Classscientific
Parametersnot in the notes
Contextnot in the notes
ReleasedDec 2024
Opennessopen weights permissive
Runs onsingle datacentre GPU
Statusactive
Lineage
finetunesuccessor
ESMFold2 is a child (finetune)medium confidencenotes
ESM-2 / ESMFold is the parent (successor)low confidencenotesWhere this comes from
Parent and child relations from model cards, Hugging Face base_model fields and the genealogy tables of the research notes. The tree shows two generations each way, 3 models. Confidence and evidence are the notes' own.
Identity
- Developer
- EvolutionaryScale
- Family
- not in the notes
- Released
- Dec 2024 sourcesinferred from page
- Weights published
- –
- Record checked
- 10 Oct 2026
Where this comes from
Developer and dates from the research notes. Release date is the vendor's public announcement; weights date is when open weights were published.
Architecture and Size
- Architecture
- other
- Total parameters
- – sources
- Active parameters
- –
- Checkpoint parameters
- –
- Note
- 300M, 600M, 6B
- Context length
- not in the notes
- Input
- molecule
- Output
- not in the notes
Where this comes from
Parameter counts as the developer states them. Where the checkpoint holds a different total, both are shown (register A16).
Openness and Access
- Openness
- open weights permissive
- Licence
- MIT License sources
- Access routes
- open weights download, API
Where this comes from
The licence file governs over registry tags and aggregator labels.
Deployment
- Runs on
- single datacentre GPU
- Footprint
- 600M single GPU; 6B via API on biohub.ai with biosecurity guardrails
- Runtimes
- not in the notes
Where this comes from
Deployment tiers and runtimes as named in the notes. Footprint is the notes' figure, not a measurement by AURION.
Indonesia
- Indonesian support
- not stated
- Regional languages
- not in the notes
- Jakarta hosting
- unknown
- Languages
- not in the notes
Where this comes from
Indonesia fields are carried on every model; unknown is an allowed value.
Benchmark Results
The notes record no benchmark result for this model.
Industry Use Cases
No industry use case links this model.
Links
DeveloperEvolutionaryScalestartup, USA
EvolutionaryScalestartup, USAModelESM CEvolutionaryScale, scientific
ESM CEvolutionaryScale, scientificUse CasesProtein Language Models and DesignHealthcareProtein Structure and ComplexesHealthcareUse cases of models in the same R&D topic; none is recorded for this model itself.
Who Runs It
PfizerContract signed, 8 Jan 2026Deployments of these use cases; none names this model.
PfizerContract signed, 8 Jan 2026Deployments of these use cases; none names this model.Organisations 1
Sources
- GitHub - Biohub/esm github.com https://github.com/evolutionaryscale/esm
To cite this page: Project AURION, AI Use-Cases Research & Innovation, "ESM C", https://aurion.semai.id/models/evolutionaryscale-esm-c/, records of October 2026.